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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Ann Neurol. 2015 Mar;77(3):469–477. doi: 10.1002/ana.24337

FIGURE 3. rs6910730 is associated with TREM1 surface expression on monocytes.

FIGURE 3

In CD33+ monocytes isolated from cryopreserved PBMCs of healthy subjects (n=139), we measured TREM1 surface expression by flow cytometric analysis. Panel (A) shows histograms of the fluorescence intensity of an isotype control (white), an rs6910730AG subject with a median level of TREM1 expression (gray), and an rs6910730AA subject with a median level of TREM1 expression (black). (B) After correcting the TREM1 MFI for batch effects and adding age, cohort, gender, and cell viability as covariates, rs6910730G was associated with decreased TREM1 surface expression (p=0.0028, β=−9.53).