Fig. 5.
Mean network activity at baseline, 24 and 48 months. Values for the PD-related motor and cognitive spatial covariance patterns (PDRP and PDCP; see Fig. 1) were computed at each timepoint and displayed relative to the mean for 15 age-matched healthy subjects (see text). Network activity increased significantly over time for both patterns (P<0.0001; RMANOVA), with the PDRP progressing faster than the PDCP (P<0.04). Relative to controls, PDRP activity in the patient group was elevated at all three timepoints, while PDCP activity reached abnormal levels only at the final timepoint. [Bars represent the standard error at each timepoint.]