Skip to main content
. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Annu Rev Biochem. 2015 Jan 26;84:739–764. doi: 10.1146/annurev-biochem-060614-034402

Figure 5. Structures of the juxtamembrane latch and the transmembrane helices of EGFR.

Figure 5

A) The asymmetric dimer of EGFR with the juxtamembrane latch highlighted in green (PDB ID 3GOP). B) An NMR structure of the transmembrane and JM-A helices of EGFR in lipid bicelles (PDB ID 2M20). Interactions between the N-terminal GxxxG-like motifs on the transmembrane segments and the LRRLL motifs of the juxtamembrane segments are highlighted in yellow.