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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Annu Rev Biochem. 2015 Jan 26;84:739–764. doi: 10.1146/annurev-biochem-060614-034402

Figure 2. Extracellular module structures for the EGFR family members.

Figure 2

A) The conformational change induced by ligand binding. The tethered conformation of EGFR (left, PDB ID 1NQL, EGF bound at low pH was removed for clarity) rearranges to the extended conformation of EGFR (right, PDB ID 3NJP) upon ligand binding. B) Unliganded Her3 (PDB ID 1M6B) and Her4 (PDB ID 2AHX) can adopt a tethered conformation similar to EGFR, while Her2 (PDB ID 1N8H) is in an extended conformation, even in the absence of ligand.