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. 2015 Apr 29;11(6):679–687. doi: 10.7150/ijbs.11589

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Adherent platelets accelerate angiogenesis via the secretion of VEGF. (A) There were fewer microvessles in the adenomas of Apc^Min/+;P-sel^-/-mice than Apc^Min/+mice. (B) IHC staining of intestinal tumors for VEGF. VEGF expression was higher in the tumors of Apc^Min/+mice than those in Apc^Min/+;P-sel^-/-mice. (C) The concentration of VEGF in small intestinal adenomas. Small intestinal adenomas from Apc^Min/+and Apc^Min/+;P-sel^-/-mice were lysed, and the amounts of VEGF were detected by ELISA. *, p<0.05; **, p<0.01;***, p<0.001. Scale bars = 50 μm.