Figure 2. Schematic model of hepcidin regulation by matriptase-2. BMP: bone morphogenetic protein, BMPR: BMP receptor, HJV: hemojuvelin, R-SMAD: receptor-associated Son of Mothers against Decapentaplegic proteins. In conditions of iron deficiency, matriptase-2 modulates hepcidin signaling by cleaving HJV from the hepatocyte plasma membrane, resulting in decreased hepcidin production.
