Table 1.
Pathway enrichment analysis of genes differentially expressed by SEMFs in response to IL-33
| Representative pathways enriched by up- or down-regulated genes* | P score |
| Up-regulated | |
| Angiogenesis (BP) | 9.68E-07 |
| ECM–receptor interaction (Kegg) | 7.60E-06 |
| TGF-beta signaling pathway (Kegg) | 3.33E-05 |
| MAPK signaling pathway (Kegg) | 4.17E-05 |
| Wound healing (BP) | 4.64E-05 |
| CRC (Kegg) | 6.92E-04 |
| Positive regulation of inflammatory response (BP) | 1.62E-03 |
| ECM organization (BP) | 6.74E-03 |
| Fibroblast growth factor receptor signaling pathway (BP) | 4.16E-02 |
| Positive regulation of collagen biosynthetic process (BP) | 1.77E-02 |
| Collagen catabolic process (BP) | 2.38E-02 |
| I-kappaB kinase/NF-kappaB cascade (BP) | 3.89E-02 |
| Down-regulated genes | |
| DNA repair (BP) | 6.52E-11 |
| Mismatch repair (Kegg) | 3.39E-04 |
| Nucleotide excision repair (Kegg) | 6.92E-04 |
| Base-excision repair (BP) | 2.37E-03 |
*
Representative pathways enriched by genes significantly increased or decreased 1.5-fold in response to IL-33. Full lists of annotated pathways and their composing genes can be found in Datasets S2 and S3. BP, Go Biological Processes; Kegg, Kegg Pathways.