Figure 6.
Synaptopathic noise exposure exacerbates spiral ganglion cell loss as animals age after noise. Representative cochlear sections from the 32 kHz region of control (A:16 weeks chronological age, unexposed); control + 88 weeks (B:104 weeks chronological age, unexposed); and 100 dB + 88 weeks (C:exposed at 16 weeks, held 88 weeks to 104 weeks chronological age) showing exaggerated loss of spiral ganglion cells in ears aged after exposure to synaptopathic noise. Scale bar in C applies to all SGN images. Cell counts in groups (means ± SE, group sizes are provided in Fig. 3 legend) with and without prior noise are displayed at two frequencies: 11.3 kHz (D) and 32 kHz (E).