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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Nat Rev Endocrinol. 2014 Oct 7;10(12):723–736. doi: 10.1038/nrendo.2014.171

Figure 1.

Figure 1

Plasma BCAA levels and insulin-resistant obesity. a | Association between plasma BCAA levels and insulin-resistant obesity in humans, obese Zucker rats, mice with diet-induced obesity (DIO) and ob/ob mice. Data were compiled from elsewhere and redrawn.63,72,73,75 b | Correlation between plasma levels of leucine and fasting levels of HbA1c in African–American women with obesity and T2DM (blue circles) and those with obesity but no T2DM (green circles). Abbreviations: BCAA, branched-chain amino acid; IR, insulin resistant; T2DM, type 2 diabetes mellitus. Adapted from Fiehn, O. et al. PLoS ONE 5, e15234 (2010),66 which is published under a Creative Commons Licence owned by PLOS ©.