Figure 2.
(A) Three-dimensional reconstructed T1-weighted magnetic resonance imaging showing gadolinium diffusion, (B–D) Horizontal fluorescence microscope images showing fluorescent 40 kDa dextran diffusion in the same brain. The area where the larger molecule diffused was smaller compared with gadolinium. A 10,000 cycles pulse length was necessary for the diffusion of the 40 kDa dextran. (E) With a 5,000 cycle, gadolinium could diffuse to the brain parenchyma but the 40 kDa dextrans could not.