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. 2015 Apr 21;75(7):731–748. doi: 10.1007/s40265-015-0386-x

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — The cycle of hypothesis generation/testing to refine the target metastatic colorectal cancer population for panitumumab treatment. ASCO American Society of Clinical Oncology, NCCN National Comprehensive Cancer Network, NGS next-generation sequencing, PCR polymerase chain reaction, PRA prospective–retrospective analysis