Table 2.
PTEN IHC score distribution
| Score | BCIRG 006 (HER2-amplified) | BCIRG 005 (HER2-not-amplified) | Overall |
|---|---|---|---|
|
| |||
| Absent in tumor1 (0) | 65 (5.4%) | 185 (15.9%) | 250 (10.6%) |
| Weak in tumor2 (1*) | 85 (7.1%) | 88 (7.6%) | 173 (7.3%) |
| Weak overall3 (1+) | 501 (41.7%) | 443 (38.1%) | 944 (39.9%) |
| Moderate overall4 (2+) | 486 (40.5%) | 387 (33.3%) | 873 (36.9%) |
| Strong in tumor5 (3+) | 64 (5.3%) | 60 (5.2%) | 124 (5.2%) |
|
| |||
| Total scorable | 1201 | 1163 | 2364 |
1
No detectable staining in tumor cells but with positive staining present in stroma.
2
Weak staining present in tumor cells; however, this staining is weaker than the immunostaining observed in adjacent benign stromal cells.
3
Weak staining (1+) present in tumor cells with similar intensity to that observed in adjacent stromal cells.
4
Moderate immunostaining (2+) with immunostaining also present in stromal cells.
5
Strong staining (3+) in tumor cells with staining also present in stromal cells.