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. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Am J Obstet Gynecol. 2014 Nov 27;212(5):569–579. doi: 10.1016/j.ajog.2014.11.036

Oxidative stress activates ASK1 signaling pathway. Oxidative stress activates ASK1 by disrupting its interaction with oxidized-thioredoxin. Free ASK1 quickly autophosphorylates and further phosphorylates JNK1/2, induces translocation of Bcl2 family members to mitochondria and apoptosis. Phospho-ASK1 can also increase nucleus transpotation of transcription factor FoxO3a, which induces TRADD expression. Up-regulation of TRADD leads to caspase 8 cleavege and apoptosis. : phosphorylation; ⇑ upregulated.

Inline graphic — Oxidative stress activates ASK1 signaling pathway. Oxidative stress activates ASK1 by disrupting its interaction with oxidized-thioredoxin. Free ASK1 quickly autophosphorylates and further phosphorylates JNK1/2, induces translocation of Bcl2 family members to mitochondria and apoptosis. Phospho-ASK1 can also increase nucleus transpotation of transcription factor FoxO3a, which induces TRADD expression. Up-regulation of TRADD leads to caspase 8 cleavege and apoptosis. : phosphorylation; ⇑ upregulated.