Fig. 2.
Proposed mechanisms of escape from DNA damage-induced cell death by mutant p53. In response to DNA damage, inhibition of p63 and p73 by mutant p53 leads to loss of p53 independent transcription of apoptosis genes, while damage induced NF-Y/p300/mutp53 transcription complexes enhances cell proliferation by upregulating cell-cycle promoting target genes. Aside from direct inhibition of p73 mediated by mutantp53/p73 complex formation, loss of Chk kinase activity and enhanced transcription of cell-cycle promoting genes can also lead to indirect inhibition of p73.