FIG 2.
Genome arrangement of MERS-CoV, with emphasis on the clinical applications of the key nonstructural and structural genes and/or gene products. *, furin cleavage sites. Abbreviations: 3CLpro, 3C-like protease; AP, accessory protein; CP, cytoplasmic domain; E, envelope; FP, fusion peptide; Hel, helicase; HR, heptad repeat; IFN, interferon; M, membrane; mAb, monoclonal antibody; N, nucleocapsid; nsp, nonstructural protein; ORF, open reading frame; PLpro, papain-like protease; RBD, receptor-binding domain; RdRp, polymerase; RT-RPA; reverse transcription isothermal recombinase polymerase amplification; S, spike; SP, signal peptide; TM, transmembrane domain.