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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: Nature. 2014 Oct 29;515(7526):209–215. doi: 10.1038/nature13772

Extended Data Figure 3. Heat map of the numbers of variants used in TADA analysis from each dataset in genes with q < 0.3.

Extended Data Figure 3

Left panel, variants in affected subjects; right panel, unaffected subjects. For the counts, we only focus on de novo LoF and Mis3 variants, transmitted/un-transmitted and case/control LoF variants. These variant counts are normalized by the length of coding regions of each gene and sample size of each dataset (|trio|+|case| for left panel, |trio|+|control| for the right panel).