Table I.
Genes Up-Regulated by PAM3 and/or R848
| Genes Up regulated by: | ||
|---|---|---|
| Only PAM3 | Only R848 | Both |
| IL8 | BCL2 | ARL5B |
| KBTD8 | BCL2A1 | BAG3 |
| NSMAF | CA2 | C13orf15 |
| OLR1 | CCL2 | CCL20 |
| CFLAR | CD44 | |
| EDN1 | CD83 | |
| EREG | CXCL1 | |
| FFAR2 | CXCL2 | |
| FLJ37505 | CXCL3 | |
| GEM | DNAJA4 | |
| KCNMA1 | ELOVL6 | |
| LOC338758 | ETNK1 | |
| LOC646329 | F3 | |
| LRRC50 | IL1A | |
| MAP3K8 | IL6 | |
| NFKBIZ | IRG1 | |
| NPR1 | KRT16P2 | |
| OR6K3 | LOC399884 | |
| PLAUR | LY6K | |
| PLLP | MIR155HG | |
| PMAIP1 | PHLDA1 | |
| PNRC1 | PURG | |
| PPP1R15A | RRAD | |
| PTGS2 | SERPINB2 | |
| RECQL4 | ST20 | |
| REPS2 | TNF | |
| RGS1 | ZC3H12C | |
| RGS20 | ZNF784 | |
| RRP7A | ||
| RRP7B | ||
| TNFAIP3 | ||
| TNFAIP6 | ||
| TRIB3 | ||
| ZNF544 | ||
mMDSC from 4 donors were purified and stimulated with PAM3 or R848 for 0, 30, 75 and 225 minutes. Results show those genes that were reproducibly up-regulated (>5-fold increase vs unstimulated cells) in all donors over this period.