Table 1.

Assessments of WINROP algorithm for prediction of severe retinopathy of prematurity

	n	Number of centres	NICU level^*	Years	Cohort definition	Alarm definition	Definition of severe ROP	Prevalence of severe ROP	Sensitivity	Specificity	PPV	NPV
Hellström et al,⁹⁸ 2009	353	1	3	2004–07	GA <32 weeks	High risk or low risk at <32 weeks’ PMA	Stage 3	10%	100	84	41	100
Flückiger et al,¹²³ 2011	376	1	3	2003–08	GA <32 weeks or birthweight <1500 g	High risk or low risk at <32 weeks’ PMA	Stage 3 or threshold	3%	90	63	6	99
Zepeda-Romero et al,¹²⁴ 2012	192	1	1	2005–10	GA <32 weeks	High-risk or low risk at <33 weeks’ PMA	Type 1	51%	85	27	54	53
Löfqvist et al,¹²¹ 2006	79	2	3	1999–2002	GA <32 weeks	··	Stage 3 or treated ROP	16%	100	84	··	··
Löfqvist et al,¹²⁵ 2009	50	1	3	2005–07	GA <31 weeks	High risk at <32 weeks’ PMA	Type 1	18%	100	54	41	··
Hård et al,¹²⁶ 2010	366	1	3	2002–08	GA <32 weeks	High risk or low risk at <32 weeks’ PMA	Stage 3	6%	91	55	11	99
Wu et al,¹²² 2010	318	1	3	2005–08	GA <32 weeks	High risk	Prethreshold or threshold and stage 3	9%	100	82	35	100
Wu et al,¹⁰⁰ 2012	1706	10	3	2006–09	GA <32 weeks	High risk or low risk at <32 weeks’ PMA	Type 1	9%	99	39	13	100

NICU=neonatal intensive care unit. ROP=retinopathy of prematurity. PPV=positive predictive value. NPV=negative predictive value. GA=gestational age. PMA=post-menstrual age.

NICU levels are 1 (special care), 2 (high-dependency care), and 3 (intensive care).