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. Author manuscript; available in PMC: 2015 Apr 6.
Published in final edited form as: Cell. 2013 Aug 1;154(4):748–762. doi: 10.1016/j.cell.2013.07.023

Figure 4. ITC Data on Binding of cGAMP Linkage Isomers to hSTINGH232 and Its Mutants, as well as to hSTINGR232, hSTINGA230/R232, mStingR231, and mStingA231.

Figure 4

(A and B) ITC binding curves for complex formation between cGAMP linkage isomers bound to hSTINGH232 (aa 140–379) (A) and binding of c[G(2′,5′ )pA(3′,5′)p] to mutants of hSTINGH232 (B).

(C) ITC binding curves for complex formation between cGAMP linkage isomers bound to hSTINGR232 (aa 140–379).

(D) ITC binding curves for complex formation between cGAMP linkage isomers bound to hSTINGA230/R232 (aa 140–379).

(E) ITC binding curves for complex formation between cGAMP linkage isomers bound to mStingR231 (aa 139–378).

(F) ITC binding curves for complex formation between cGAMP linkage isomers bound to mStingA231 (aa 139–378).

Relates to Tables S3 and S4.