Table 3. Association between PNPLA3 polymorphism and NAFLD risk.
| Subgroup | Inherited model | Study number | NO. of cases/controls(n/n) | Pheterogeneity | I2 (%) | Pooled OR (95%CI) | P valuea |
|---|---|---|---|---|---|---|---|
| Total studies | Allele contrast | 22 | 11838/18552 | P < 0.00001 | 89 | 2.10 (1.78, 2.48) | P < 0.00001 |
| Dominant model | 19 | 4709/7328 | P < 0.0001 | 67 | 2.06 (1.75, 2.43) | P < 0.00001 | |
| Recessive model | 18 | 4560/7243 | P < 0.0001 | 72 | 2.49 (2.01, 3.08) | P < 0.00001 | |
| Additive model | 18 | 2523/3886 | P < 0.00001 | 77 | 3.41 (2.57,4.52) | P < 0.00001 | |
| Studies excluded for DHWE | |||||||
| Allele contrast | 21 | 10798/17880 | P < 0.00001 | 89 | 2.05 (1.74, 2.42) | P < 0.00001 | |
| Dominant model | 18 | 4560/7243 | P < 0.00001 | 69 | 2.02 (1.84, 2.20) | P < 0.00001 | |
| Recessive model | 18 | 4560/7243 | P < 0.00001 | 72 | 2.51 (2.28, 2.77) | P < 0.00001 | |
| Additive model | 18 | 2523/3886 | P < 0.00001 | 77 | 3.32 (2.94, 3.74) | P < 0.00001 | |
| Ethnicity | |||||||
| Caucasian | Allele contrast | 9 | 4858/5496 | P < 0.0001 | 75 | 2.56 (2.06, 3.18) | P < 0.00001 |
| Dominant model | 7 | 1363/998 | P = 0.60 | 0 | 2.21 (1.83, 2.67) | P < 0.00001 | |
| Recessive model | 6 | 1214/913 | P = 0.35 | 10 | 2.68 (1.78, 4.05) | P < 0.00001 | |
| Additive model | 6 | 704/617 | P = 0.27 | 22 | 3.79 (2.35, 6.13) | P < 0.00001 | |
| Asian | Allele contrast | 12 | 6838/12822 | P < 0.00001 | 88 | 1.82 (1.52,2.18) | P < 0.00001 |
| Dominant model | 11 | 3275/6213 | P < 0.00001 | 78 | 1.95 (1.56, 2.43) | P < 0.00001 | |
| Recessive model | 11 | 3275/6213 | P < 0.00001 | 81 | 2.33 (1.81, 2.99) | P < 0.00001 | |
| Additive model | 11 | 1778/3212 | P < 0.00001 | 84 | 3.08 (2.21, 4.31) | P < 0.00001 | |
| Hispanics | Allele contrast | 1 | 142/234 | NA | NA | 3.09 (1.99, 4.80) | P < 0.00001 |
| Dominant model | 1 | 71/117 | NA | NA | 4.40 (1.84, 10.51) | P = 0.0009 | |
| Recessive model | 1 | 71/117 | NA | NA | 4.74 (2.41, 9.33) | P < 0.00001 | |
| Additive model | 1 | 41/57 | NA | NA | 9.71 (3.64, 25.94) | P < 0.00001 | |
| Control source | |||||||
| Population based | Allele contrast | 7 | 4076/5836 | P < 0.00001 | 90 | 2.17 (1.60, 2.95) | P < 0.00001 |
| Dominant model | 7 | 2038/2918 | P < 0.00001 | 82 | 2.47 (2.14, 2.85) | P < 0.00001 | |
| Recessive model | 7 | 2038/2918 | P < 0.00001 | 83 | 3.04 (2.00,4.62) | P < 0.00001 | |
| Additive model | 7 | 1139/1542 | P < 0.00001 | 87 | 4.61 (2.58, 8.23) | P < 0.00001 | |
| Hospital based | Allele contrast | 15 | 7762/12716 | P < 0.00001 | 89 | 2.07 (1.68, 2.54) | P < 0.00001 |
| Dominant model | 12 | 2671/4410 | P = 0.65 | 0 | 1.76 (1.57,1.97) | P < 0.00001 | |
| Recessive model | 11 | 2522/4325 | P = 0.26 | 19 | 2.10 (1.78, 2.47) | P < 0.00001 | |
| Additive model | 11 | 1384/2344 | P = 0.34 | 11 | 2.62 (2.20, 3.13) | P < 0.00001 | |
| Age of participants | |||||||
| Adult | Allele contrast | 18 | 10746/15072 | P < 0.00001 | 90 | 2.19 (1.82, 2.62) | P < 0.00001 |
| Dominant model | 15 | 4163/5588 | P < 0.0001 | 70 | 2.10 (1.74, 2.54) | P < 0.00001 | |
| Recessive model | 14 | 4014/5503 | P < 0.00001 | 75 | 2.59 (2.01, 3.34) | P < 0.00001 | |
| Additive model | 14 | 2248/2978 | P < 0.00001 | 79 | 3.54 (2.54, 4.94) | P < 0.00001 | |
| Pediatric | Allele contrast | 4 | 1092/3480 | P = 0.01 | 73 | 1.73 (1.31, 2.29) | P = 0.0001 |
| Dominant model | 4 | 546/1740 | P = 0.09 | 54 | 1.89 (1.34, 2.66) | P < 0.00001 | |
| Recessive model | 4 | 546/1740 | P = 0.07 | 58 | 2.18 (1.47, 3.22) | P < 0.0001 | |
| Additive model | 4 | 275/908 | P = 0.03 | 66 | 2.97 (1.75, 5.02) | P < 0.0001 |
a: Test for overall effect. NA: Not applicable.