| Neutralizing Ab to receptor tyrosine kinase (cKit)92
|
Growth factor |
Colon carcinoma (mice) |
Inhibition of proliferation |
| Prokineticin 2 (PROK2)-specific Ab183
|
Growth factor |
Tumours of human & mouse origin in nude mice |
Inhibition of PMN/MDSC expansion & tumour recruitment |
| Neutralizing Ab to granulocyte-macrophage colony-stimulating factor (GM-CSF)15
|
Growth factor |
Pancreatic Cancer (mice) |
Inhibition of proliferation |
| Neutralizing Ab to granulocyte colony-stimulating factor (G-CSF)42
|
Growth factor |
Colon carcinoma (mice) |
Inhibition of proliferation |
| Colony stimulating factor 1 receptor (CSF1R) & protein kinase (KIT) tyrosine kinase inhibitor (TKI) (PLX3397)97
|
Growth factor |
Breast cancer (human) |
Inhibition of TAM recruitment |
| CSF1R antagonist (GW2580)96
|
Growth factor |
Lung carcinoma & prostate cancer (mice) |
Inhibition of MDSC & macrophage proliferation |
| Vascular endothelial growth factor (VEGF)-trap98
|
Growth factor |
Solid tumours (human) |
No activity |
| Ab to VEGF (Avastin)185
|
Growth factor |
Metastatic renal cell carcinoma (RCC) (human) |
Weak inhibition of proliferation |
| Ab to interleukin 6 receptor (IL-6R) & gemcitabine141
|
Interleukin & Cytotoxic |
Carcinoma (mice) |
Inhibits accumulation of Mo- & G-MDSCs |
| CXC chemokine receptor 2 (CXCR2) (S-265610) & CXCR4 (AMD3100) antagonists151
|
Chemokine |
mammary cancer (mice) |
Altered recruitment of iMCs to the tumour |
| Neutralizing Ab to chemokine (C-C motif) ligand 2 (CCL2)192
|
Chemokine |
Mammary carcinoma (mouse & human xenografts) |
Targeting inflammatory monocytes & macrophages |
| Gemcitabine145
|
Cytotoxic |
Lung & mammary cancer (mice) |
Inhibition of proliferation |
| Doxorubicin-cyclophosphamide10
|
Cytotoxic |
Breast cancer (human) |
Weak inhibition of proliferation |
| 5-fluorouracil142
|
Cytotoxic |
Thymoma (mice) |
Inhibition of MDSC expansion |
| Docetaxel143
|
Cytotoxic |
Mammary carcinoma (mice) |
Inhibition of MDSC expansion & macrophage polarization to M1 phenotype |
| Cyclooxygenase 2 (COX2) inhibitor (Celebrex)181
|
Enzyme inhibitor (Inhib.) |
Mammary carcinoma (mice) |
Inhibition of proliferation/activation |
| Amino-biphosphonate180, 193
|
Enzyme inhib. |
Mammary tumours (mice) |
Inhibition of proliferation |
| Phosphodiesterase-5 (PDE5) inhibitors144
|
Enzyme inhib. |
Mammary and colon carcinoma and fibrosarcoma (mice) |
Inhibition of proliferation & T-cell suppression |
| TKI (sunitinib)67, 95, 182, 184
|
Signal inhib. |
RCC (human) |
Inhibition of proliferation |
| Peroxisome proliferator–activated receptor-g (PPARg) inhibitor179
|
Signal inhib. |
Carcinoma & myeloid sarcoma (mice) |
Induces proliferation of MDSCs |
