FIG. 6.
Rates of change in vascular hemoglobin concentration within tumors. Both mock- and microbeam-treated tumors showed a consistent increase in vascular hemoglobin concentration over the entire time course. In contrast, concentrations within wide-field-treated tumors tended to remain static (panel A). Between the day of treatment and the third day post, no significant differences in the rate of change were observed among the treatment groups (panel B). From day 3–7, however, the microbeam group had a rate of change significantly greater than either the mock or wide-field groups (panel C) (P = 0.0285 and P = 0.0270, respectively). When the rates of change were compared over the two timeframes, only the microbeam-treated tumors showed a significant change (panel D) (P = 0.0215).