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. Author manuscript; available in PMC: 2015 Jun 23.
Published in final edited form as: Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877

Fig. 1. Strategy for manipulating oncogenic signaling pathways.

Fig. 1

Pathway names are indicated in bold and situated in the cellular context in which they function. The engineered cDNA constructs in each pathway are denoted as either wild-type (WT; black), constitutively active mutants (red), or dominant-negative mutants (blue).