Table IV.
Distribution of the DSL rank based on the Step-1 screening test from the EDG×E and ocktail methods
| Mean Rank** |
Distribution of Step-2 Testing Bins*** | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Model* | Method | 1 | 2 | 3 | 4 | 5 | >=6 | ||
| Base | EDG×E | 2.3 | 82% | 5% | 4% | 2% | 2% | 5% | |
| Cocktail | 42.4 | 30% | 9% | 9% | 8% | 8% | 36% | ||
| Marginal ORG | |||||||||
| 1.1 | EDG×E | 21.0 | 44% | 10% | 8% | 6% | 6% | 26% | |
| Cocktail | 62.2 | 30% | 8% | 6% | 7% | 7% | 42% | ||
| 1.3 | EDG×E | 1.1 | 98% | 1% | 1% | 0% | 0% | 0% | |
| Cocktail | 3.3 | 73% | 8% | 5% | 3% | 3% | 8% | ||
| DSL-E Association | |||||||||
| ORDSL-E=0.8 | EDG×E | 1,011 | 7% | 5% | 5% | 5% | 6% | 72% | |
| Cocktail | 2,593 | 9% | 6% | 5% | 6% | 6% | 68% | ||
| ORDSL-E=1.2 | EDG×E | 1.5 | 100% | 0% | 0% | 0% | 0% | 0% | |
| Cocktail | 17.4 | 47% | 9% | 7% | 6% | 7% | 24% | ||
| G-E Association | |||||||||
| 10 SNPs | EDG×E | 17.4 | 0% | 80% | 9% | 3% | 2% | 6% | |
| Cocktail | 91.0 | 0% | 28% | 14% | 10% | 10% | 38% | ||
| 50 SNPs | EDG×E | 63.9 | 0% | 0% | 0% | 88% | 5% | 7% | |
| Cocktail | 178.5 | 0% | 0% | 0% | 43% | 16% | 41% | ||
| G-D Association | |||||||||
| 10 SNPs | EDG×E | 5.2 | 73% | 12% | 5% | 4% | 2% | 4% | |
| Cocktail | 62.5 | 18% | 17% | 10% | 9% | 8% | 38% | ||
*
See Table 3 for a description of Models
**
Geometric mean across replicate simulations of the DSL rank based on Step 1.
Total number of SNPs = 1 million
***
Bin 1 includes the 5 top ranked SNPs based on Step 1 p-value, Bin 2 includes ranks 6 – 15, Bin 3 16–35, Bin 4 36–75, Bin 5 76–155, and the last column ranks 156 - 1 million