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Analysis of 536,857 SNPs for G × Sex interaction with young-onset childhood asthma using the EDG×E method. Shown are the QQ plot from Step 1 and the Manhattan plot from weighted Step-2 testing, with testing-bin assignment in Step 2 determined by Step-1 screening p-value. The initial bin size is B=5 SNPs, and each successive bin includes twice as many SNPs as the preceding bin.
