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. 2015 Mar 2;208(5):501–512. doi: 10.1083/jcb.201409063

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© 2015 Rutkowski et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Benign and unhealthy adipose tissue. The overall health of adipose tissue can be visualized histologically. Benign murine subcutaneous adipose tissue (left; trichrome staining) is rich in unilocular white adipocytes with sparse ECM. On high-fat feeding (right), adipose tissue experiences hypoxia and inflammation, resulting in a dense, fibrous ECM. These histological tissue features are characteristic of insulin-resistant adipocytes.