Fig. 5.
High-fat diet (HFD) elevates blood pressure in Cav1 knockout mice. Effect of 15-wk HFD on body weight (A), on the weight of various organs [liver, heart, epididymal fat (EpidF), and retroperitoneal fat (RertoF); B], and on systolic (Syst) and diastolic (Diast) blood pressure (C) in normal wild-type (WT) and Cav1 knockout (Cav-KO) mice is shown. Representative Western blot and summary of densitometry data (D; n = 4 in each group) showing Cav1 expression in skeletal muscle artery of WT mice with our without HFD are shown. Data are means ± SE. Asterisks indicate significant differences (P < 0.05).