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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: Nature. 2015 Feb 12;518(7538):187–196. doi: 10.1038/nature14132

Table 1. WHRadjBMI loci achieving genome-wide significance (P<5×10−8) in sex-combined and/or sex-specific meta-analyses.
Sex-combined Women Men Sex diff.Pb
SNP Chr Locus EAa EAF β P N β P N β P N
Novel loci achieving genome-wide significance in European-ancestry meta-analyses
rs905938 1 DCST2 T 0.74 0.025 7.3E-10 207,867 0.034 4.9E-10 115,536 0.015 1.10E-02 92,461 1.6E-02
rs10919388 1 GORAB C 0.72 0.024 3.2E-09 181,049 0.033 4.8E-10 102,446 0.013 2.98E-02 78,738 9.8E-03
rs1385167 2 MEIS1 G 0.15 0.029 1.9E-09 206,619 0.023 4.0E-04 114,668 0.036 2.32E-07 92,085 1.6E-01
rs1569135 2 CALCRL A 0.53 0.021 5.6E-10 209,906 0.023 6.9E-07 116,642 0.019 1.48E-04 93,398 5.8E-01
rs10804591 3 PLXND1 A 0.79 0.025 6.6E-09 209,921 0.040 6.1E-13 116,667 0.004 5.28E-01 93,387 5.7E-06
rs17451107 3 LEKR1 T 0.61 0.026 1.1E-12 207,795 0.023 1.0E-06 115,735 0.030 1.42E-08 92,194 3.5E-01
rs3805389 4 NMU A 0.28 0.012 1.5E-03 209,218 0.027 4.6E-08 116,226 −0.007 2.09E-01 93,125 1.6E-06
rs9991328 4 FAM13A T 0.49 0.019 4.5E-08 209,925 0.028 3.4E-10 116,652 0.007 1.69E-01 93,407 8.5E-04
rs303084 4 SPATA5-FGF2 A 0.80 0.023 3.9E-08 209,941 0.029 3.4E-07 116,662 0.016 9.91E-03 93,412 1.1E-01
rs9687846 5 MAP3K1 A 0.19 0.024 7.1E-08 208,181 0.041 3.8E-12 115,897 0.000 9.69E-01 92,417 1.3E-06
rs6556301 5 FGFR4 T 0.36 0.022 2.6E-08 178,874 0.018 7.1E-04 101,638 0.029 1.00E-06 77,370 1.4E-01
rs7759742 6 BTNL2 A 0.51 0.023 4.4E-11 208,263 0.024 1.7E-07 115,648 0.023 5.49E-06 92,749 8.6E-01
rs1776897 6 HMGA1 G 0.08 0.030 1.1E-05 177,879 0.052 6.8E-09 100,516 0.003 7.42E-01 77,497 1.8E-04
rs7801581 7 HOXA11 T 0.24 0.027 3.7E-10 195,215 0.025 7.7E-06 108,866 0.029 2.39E-06 86,483 6.9E-01
rs7830933 8 NKX2-6 A 0.77 0.022 7.4E-08 209,766 0.037 1.2E-12 116,567 0.001 8.35E-01 93,333 1.4E-06
rs12679556 8 MSC G 0.25 0.027 2.1E-11 203,826 0.033 2.1E-10 114,369 0.017 4.15E-03 89,591 2.8E-02
rs10991437 9 ABCA1 A 0.11 0.031 1.0E-08 209,941 0.040 2.8E-08 116,644 0.022 6.13E-03 93,430 7.2E-02
rs7917772 10 SFXN2 A 0.62 0.014 5.6E-05 209,642 0.027 5.5E-09 116,514 −0.001 8.57E-01 93,263 2.3E-05
rs11231693 11 MACROD1-VEGFB A 0.06 0.041 4.5E-08 198,072 0.068 2.7E-11 110,164 0.009 4.20E-01 88,043 2.5E-05
rs4765219 12 CCDC92 C 0.67 0.028 1.6E-15 209,807 0.037 1.0E-14 116,592 0.018 5.32E-04 93,350 5.7E-03
rs8042543 15 KLF13 C 0.78 0.026 1.2E-09 208,255 0.023 6.7E-05 115,760 0.030 1.01E-06 92,629 3.6E-01
rs8030605 15 RFX7 A 0.14 0.030 8.8E-09 208,374 0.031 1.0E-05 115,864 0.031 5.91E-05 92,644 9.9E-01
rs1440372 15 SMAD6 C 0.71 0.024 1.1E-10 207,447 0.022 1.1E-05 115,201 0.027 1.39E-06 92,380 5.2E-01
rs2925979 16 CMIP T 0.31 0.018 1.2E-06 207,828 0.032 3.4E-11 115,431 −0.002 7.86E-01 92,531 1.2E-06
rs4646404 17 PEMT G 0.67 0.027 1.4E-11 198,196 0.034 5.3E-11 115,337 0.017 2.45E-03 87,857 2.6E-02
rs8066985 17 KCNJ2 A 0.50 0.018 1.4E-07 209,977 0.026 4.0E-09 116,683 0.007 1.89E-01 93,428 1.8E-03
rs12454712 18 BCL2 T 0.61 0.016 1.0E-04 169,793 0.035 1.1E-09 96,182 −0.007 2.45E-01 73,576 1.6E-07
rs12608504 19 JUND A 0.36 0.022 8.8E-10 209,990 0.017 2.6E-04 116,689 0.028 1.05E-07 93,435 1.2E-01
rs4081724 19 CEBPA G 0.85 0.035 7.4E-12 207,418 0.033 9.2E-07 115,322 0.039 1.41E-07 92,230 5.0E-01
rs979012 20 BMP2 T 0.34 0.027 3.3E-14 209,941 0.026 1.0E-07 116,668 0.028 6.59E-08 93,407 6.7E-01
rs224333 20 GDF5 G 0.62 0.020 2.6E-08 208,025 0.009 7.4E-02 115,803 0.036 9.00E-12 92,356 6.4E-05
rs6090583 20 EYA2 A 0.48 0.022 6.2E-11 209,435 0.029 2.8E-10 116,382 0.015 2.37E-03 93,187 3.2E-02
Novel loci achieving genome-wide significance in all-ancestry meta-analyses
rs1534696 7 SNX10 C 0.43 0.011 1.3E-03 212,501 0.027 2.1E-08 118,187 −0.006 2.64E-01 92,243 2.1E-06
Previously reported loci achieving genome-wide significance in European-ancestry meta-analyses
rs2645294 1 TBX15-WARS2 T 0.58 0.031 1.7E-19 209,808 0.035 1.5E-14 116,596 0.027 1.46E-07 93,346 2.0E-01
rs714515 1 DNM3-PIGC G 0.43 0.027 4.4E-15 203,401 0.029 1.8E-10 113,939 0.025 8.54E-07 89,596 5.1E-01
rs2820443 1 LYPLAL1 T 0.72 0.035 5.3E-21 209,975 0.062 5.7E-35 116,672 0.002 6.91E-01 93,437 2.6E-17
rs10195252 2 GRB14-COBLL1 T 0.59 0.027 5.9E-15 209,395 0.052 4.7E-30 116,329 −0.003 5.33E-01 93,199 2.4E-17
rs17819328 3 PPARG G 0.43 0.021 2.4E-09 208,809 0.035 4.6E-14 116,072 0.005 3.26E-01 92,871 5.1E-06
rs2276824 3 PBRM1c C 0.43 0.024 3.2E-11 208,901 0.028 3.7E-09 116,128 0.020 1.35E-04 92,907 2.0E-01
rs2371767 3 ADAMTS9 G 0.72 0.036 1.6E-20 194,506 0.056 1.2E-26 108,624 0.012 3.49E-02 86,016 3.6E-09
rs1045241 5 TNFAIP8-HSD17B4 C 0.71 0.019 4.4E-07 209,710 0.035 6.6E-12 116,560 −0.001 9.29E-01 93,284 8.3E-07
rs7705502 5 CPEB4 A 0.33 0.027 4.7E-14 209,827 0.027 1.9E-08 116,609 0.027 2.30E-07 93,352 1.0E+00
rs1294410 6 LY86 C 0.63 0.031 2.0E-18 209,830 0.037 1.6E-15 116,624 0.025 1.37E-06 93,340 6.3E-02
rs1358980 6 VEGFA T 0.47 0.039 3.1E-27 206,862 0.060 3.7E-34 115,047 0.015 4.02E-03 91,949 3.7E-11
rs1936805 6 RSPO3 T 0.51 0.043 3.6E-35 209,859 0.052 3.7E-30 116,602 0.031 3.08E-10 93,392 1.0E-03
rs10245353 7 NFE2L3 A 0.20 0.035 8.4E-16 210,008 0.041 7.9E-13 116,704 0.027 1.43E-05 93,438 7.2E-02
rs10842707 12 ITPR2-SSPN T 0.23 0.032 4.4E-16 210,023 0.041 6.1E-15 116,704 0.022 1.44E-04 93,453 1.1E-02
rs1443512 12 HOXC13 A 0.24 0.028 6.9E-13 209,980 0.040 1.1E-14 116,688 0.013 2.77E-02 93,425 1.6E-04
rs2294239 22 ZNRF3 A 0.59 0.025 7.2E-13 209,454 0.028 6.9E-10 116,414 0.024 2.31E-06 93,173 5.0E-01

P values and β coefficients for the association with WHRadjBMI in the meta-analyses of combined GWAS and Metabochip studies. The smallest P value for each SNP is shown in bold.

a

The effect allele is the WHRadjBMI-increasing allele in the sex-combined analysis.

b

Test for sex difference; values significant at the table-wise Bonferroni threshold of 0.05/49=1.02× 10−3 are marked in bold.

c

Locus previously named NISCH-STAB1. Additional analyses that showed no significant evidence of heterogeneity between studies or due to ascertainment are provided in Supplementary Tables 27 and 28 (Supplementary Note). Chr, chromosome; EA, effect allele; EAF, effect allele frequency.