Extended Data Figure 10. Intra- and inter-domain interactions that may be important for the long-range allosteric regulation of channel gating.
a, Extensive van der Waals interactions exist between the pore-forming segments, and between the VSL of one protomer and S6 of adjacent protomer. These extensive interactions may aid the coupling of conformational changes within the channel domain. One protomer is color coded, whereas the adjacent one is colored silver. b, A stereo view of the polar interaction network between the Central domain and CTD. Potential H-bonds are shown as red dashed lines. c, The van der Waals contacts between the U-motif of the Central domain and the CTD. Two opposite views are shown. d, Interactions between the Central domain and the VSL. Polar and van der Waals contacts are shown on the left and right, respectively.