. 2015 Jan 14;89(6):3380–3395. doi: 10.1128/JVI.03473-14

TABLE 2.

Thermodynamic parameters of 19b, PGT151, and PGT145 binding to B41 and BG505 SOSIP.664 trimers measured by ITC^a

Antibody group and epitope	Binding expt	ΔG (kcal mol⁻¹)	ΔH (kcal mol⁻¹)	−TΔS (kcal mol⁻¹)	K_d (nM)	N
Non-NAb, V3	19b IgG into BG505	−10.6	−41.4	30.8	21	0.1
Non-NAb, V3	19b IgG into B41	−11.9	−39.5	27.6	3	0.2
bNAb, gp120-gp41_ECTO interface	PGT151 Fab into BG505^b	−9.3	−23.8	14.5	130	1.3
bNAb, gp120-gp41_ECTO interface	PGT151 Fab into B41	No detectable binding	No detectable binding	No detectable binding	No detectable binding	No detectable binding
bNAb, trimer apex	PGT145 Fab into BG505	−9.9	−3.3	−6.6	63	0.5
bNAb, trimer apex	PGT145 Fab into B41	−10.9	−13.2	−2.3	9	0.4

Reported values are averages from at least two independent measurements; associated errors are ∼10% of the average. Representative isotherms can be found in Fig. 4.

Previously reported in reference 28.