Fig. 4.
Renal blood flow (RBF) and renal vascular resistance (RVR) correction after a step increase in mean arterial pressure (MAP). A–F: time course of the response of MAP (A and D), RBF (B and E), and RVR (C and F) in ASIC2 mice to a step increase in MAP in ASIC2+/+ (solid diamonds, n = 9), ASIC2+/− (shaded squares, n = 7), and ASIC2−/− (open triangles, n = 11) mice. The time course shows the responses 15 s before and 20 s after the step increase in pressure (time 0). Absolute values are shown in A–C, whereas values normalized to baseline (%baseline) are shown in D–F. KW, kidney weight; RU, resistance units. G–I: changes in MAP (G), RBF (H), and RVR (I) at the time period indicated from baseline. Morphological characteristics and baseline hemodynamic parameters are shown in Table 2. Data are means ± SE. *Significantly different compared with ASIC2+/+ mice (P < 0.05).