Figure 6.
Toxicity monitoring after adoptive transfer of a high dose of ROR1 CAR-T cells. A, serum chemistry of macaque A13011 and A13002 before and at the indicated days after infusion of ROR1 CAR-T cells (5×108/kg) and tROR1+T-APC challenge. Pancreatic, liver, and muscle enzymes, and glucose were measured in an accredited laboratory. The grey shaded area demarks the macaque specific normal range for each parameter. B, plasma IFNγ and IL6 levels before and at the indicated days after the T-cell infusion. Shown are data from macaque A13011. C, plasma adiponectin levels in animals A11047, A13011, and A13002 on the indicated days after the ROR1 CAR-T cell infusion. D, plasma adiponectin levels in control animals undergoing blood draw procedures alone (A12012) or receiving control gene-modified T cells (A12022, A13003).