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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Neurobiol Dis. 2014 Nov 4;74:114–125. doi: 10.1016/j.nbd.2014.10.024

Figure 6. Fibrotic scar reduction is associated with increased growth of neurofilament+ axons.

Figure 6

At 14 days after SCI, the number of neurofilament+ axons in the fibrotic scar (GFAP− region) was similar between PBS (A–C, n=3) and clodronate liposome (D–F, n=4) treated animals (M). However, at 56 days after SCI, the number of neurofilament+ axons in the clodronate liposome treated animals (J–L, M, n=7) was significantly higher than PBS liposome treated controls (G–I, M, n=7). The GFAP− area was smaller in clodronate liposome treated animals at 56 days after injury (N). Region of interest (ROI) represents boxed region to the left. *p<0.05 compared to the other groups using two way ANOVA with Tukey’s post-test in M or two tailed student’s t-test in N. Scale bar in A = 500 μm; in C = 50 μm. PBS = PBS liposome. CLO = Clodronate liposome. Error bars are s.e.m.