Figure 2.
The first partition of the pan-cancer data set identifies two main classes primarily characterized by either recurrent mutations (M class) or recurrent copy number alterations (C class). (a) Each class is composed of multiple tumor types in different proportions. (b) SFEs were tested for significant enrichment (more frequent than expected in a random distribution) in each class (events along the x axis, log-scaled q values on the y axis). Highly enriched events are primarily mutations in the M class and copy number alterations in the C class. Mut, mutation; meth, methylation change; amp, amplification; del, deletion. (c) The distribution of SFEs in tumors indicates that the number of copy number alterations in a sample (x axis) is approximately anticorrelated with the number of somatic mutations in a sample (y axis). The number of samples for a given (x,y) position range from 0 (white) to 243 (dark blue). CNAs, copy number alterations. Tumor types abbreviated as in Table 1.