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. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Alcohol Clin Exp Res. 2014 Dec 16;39(1):136–145. doi: 10.1111/acer.12610

A. PPARA and withdrawal B. PPARG and withdrawal C. PPARGC1A and AD. Y-axis denotes the –log₁₀ (p-value) for association. X-axis is the physical position on the chromosome (Mb). The most significantly associated SNP is denoted with a purple symbol, and the SNP name is shown below the color scale. The extent of linkage disequilibrium (LD, as measured by r²) between each SNP and the most significantly associated SNP with the lowest p-value within the gene is indicated by the color scale. Larger values of r² indicate greater LD. Association results with genotyped SNPs are shown as a circle while association results with imputed SNPs are shown as a square.

A. PPARA and withdrawal B. PPARG and withdrawal C. PPARGC1A and AD. Y-axis denotes the –log₁₀ (p-value) for association. X-axis is the physical position on the chromosome (Mb). The most significantly associated SNP is denoted with a purple symbol, and the SNP name is shown below the color scale. The extent of linkage disequilibrium (LD, as measured by r²) between each SNP and the most significantly associated SNP with the lowest p-value within the gene is indicated by the color scale. Larger values of r² indicate greater LD. Association results with genotyped SNPs are shown as a circle while association results with imputed SNPs are shown as a square.