Table 3. A: Univariate analyses of progression-free and overall survival in endometrioid EC.
| Variable | Progression-free survival | Overall Survival | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value* | |
| Advanced age (≥60 y) | 1.53 (0.93-2.52) | .09 (NS) | 2.32 (1.64-3.26) | <.001 |
| Advanced stage (I/II vs III/IV) | 4.98 (3.11-7.97) | <.001 | 3.03 (2.18-4.23) | <.001 |
| Grade 1 vs 2 | 2.81 (1.52-5.18) | 0.001 | 1.75 (1.24-2.46) | .001 |
| Grade 1 vs 3 | 7.49 (4.01-13.98) | <.001 | 4.17 (2.84-6.12) | <.001 |
| Presence of LVSI | 3.94 (2.42-6.42) | <.001 | 2.61 (1.94-3.53) | <.001 |
| Deep myometrial invasion (≥50%) | 3.41 (2.09-5.55) | <.001 | 2.01 (1.48-2.72) | <.001 |
| Adjuvant therapy (any kind) | 3.13 (1.95-5.01) | <.001 | 1.68 (1.25-2.27) | .001 |
| BMI ≥30 mg/m2 | 0.99 (0.97-1.02) | .574 (NS) | 0.98 (0.97-1.00) | .085 (NS) |
| POLE mutation | 0.22 (0.03-1.55) | .127 (NS) | 0.27 (0.08-0.83) | .023 (NS) |
|
| ||||
| *In order to correct for multiple comparisons, a P value ≤0.01 was considered significant. | ||||
| B: Multivariable analysis of progression-free and overall survival in endometrioid EC | ||||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Variable | Progression-free survival | Overall Survival | ||||||
| Hazard ratio (95% CI) | Std. Error | z | P value | Hazard ratio (95% CI) | Std. Error | z | P value | |
| Advanced age (>60 y) | 1.21 (0.72-2.06) | .326 | 0.72 | .472 | 2.02 (1.35-3.01) | .413 | 3.42 | .001 |
| Advanced stage (I/II vs III/IV) | 2.65 (1.39-5.07) | .876 | 2.96 | .003 | 2.95 (1.74-5.00) | .795 | 4.01 | <.001 |
| High grade (1 vs 2/3) | 2.51 (1.36-4.62) | .782 | 2.96 | .003 | 1.51 (1.06-2.16) | .275 | 2.28 | .023 |
| Presence of LVSI | 1.80 (1.02-3.18) | .523 | 2.03 | .042 | 1.60 (1.10-2.33) | .308 | 2.45 | .014 |
| Deep myometrial invasion (≥50%) | 1.59 (0.88-2.87) | .478 | 1.55 | .122 | 1.38 (0.92-2.07) | .285 | 1.57 | .117 |
| Adjuvant therapy (any kind) | 0.99 (0.52-1.88) | .324 | -0.05 | .964 | 0.65 (0.40-1.05) | .16 | -1.76 | .079 |
| BMI ≥30 mg/m2 | - | - | - | - | 1.00 (0.98-1.02) | .01 | -0.17 | .863 |
| POLE mutation | - | - | - | - | 0.37 (0.09-1.54) | .27 | -1.37 | .172 |
Variables with a p value <0.1 in univariate analysis were included in the multivariable model. Std. error: standard error.