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. 2015 Jan 1;142(1):31–40. doi: 10.1242/dev.111104

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© 2015. Published by The Company of Biologists Ltd

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Fig. 5. — Mga^Gt/Gt embryos showed more apoptosis, but cell proliferation and differentiation were normal at E4.5. Cell proliferation, as measured by phospho-H3 immunostaining, was similar in Mga^Gt/Gt compared with Mga^+/+ and Mga^Gt/+ embryos. Confocal Z-stacks of cleaved caspase 9 immunofluorescence showed that more Mga^Gt/Gt embryos had fragmented nuclei (7/9) than did Mga^+/+ and Mga^Gt/+ embryos (7/47). The pluripotency markers NANOG and POU5F1, as measured by a GFP reporter, are similar in Mga^Gt/Gt embryos compared with Mga^+/+ and Mga^Gt/+ embryos, as was the PE marker GATA4. Numbers in the panels indicate the number of embryos out to the total with an appearance similar to that shown.