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. Author manuscript; available in PMC: 2015 Jan 14.
Published in final edited form as: Chem Rev. 2013 Aug 6;113(11):8583–8603. doi: 10.1021/cr400105n

Figure 5. The productive elongation complex.

Figure 5

P-TEFb is recruited by BRD4 and triggers the transition into productive elongation. DSIF is phosphorylated turning it into a productive elongation factor and NELF is removed from the elongation complex. The CTD becomes phosphorylated on Ser2, which promotes mRNA processing. Components of SEC and Paf1C interact with both Pol II and Mediator. TFIIS facilitates release of the paused polymerase into productive elongation.