Fig. 5.
Food-maintained operant responding was attenuated by THC, JZL184, and SA-57, but PF-3845 had no effect. (A) THC produced a significant dose-related reduction of operant responding, as shown by a main effect of drug treatment (F3, 36 = 11.06, P < 0.001; n = 13). (B) PF-3845 did not alter operant responding for food (F3, 28 = 0.50, P = 0.69; n = 8). (C) JZL184 attenuated operant responding for food (F4, 32 = 9.89, P < 0.001; n = 9). (D) SA-57 significantly reduced operant responding for food (F4, 32 = 19.03, P < 0.001; n = 9). *P < 0.05; **P < 0.01; ***P < 0.001 versus respective VEH group (Dunnett’s post hoc test). All values represent mean ± S.E.M.