Table 2.
An outline of targeted nanodevices as radiosensitizers in head and neck cancer therapy
| Targeting antigen | Nanoparticles | Radiosensitization | Ref. |
|---|---|---|---|
| folate receptor | Polymeric NPs | FT-NP Dtxl | 144 |
| EGFR | PLGA NPs | antisense-EGFR NPs | 149 |
| Carbon NPs | Cet-targeted PTX-load carbon NPs (noncovalent assembly) |
104 | |
| ATM | PLGA NPs | Antisense-ATM NPs | 150 |
| Hsp27 | lipofectamine | lipofectamine-carried Hsp27 ASOs lipofectamine-carried Hsp27 siRNA |
156 157 |
| MnSOD | Liposome | MnSOD-plasmid liposome MnSOD-plasmid liposome+ Gefitinib |
162, 163 |
| SphK1 | Au-NP | SphK1 siRNA -AuNP | 170 |
Abbreviations: NPs, nanoparticles; FR, folate receptor; Dtxl, docetaxel; EGFR, Epidermal growth factor receptor; PLGA, poly lactic-co-glycolic acid; Cet, Cetuximab; PTX, paclitaxel; ATM, ataxia-telangiectasia-mutated; MnSOD, manganese superoxide dismutase; SphK1, sphingoid base Sphingosine K1.