FIG 1.
Observed amino acid substitutions in Erg11 in C. albicans compared to those in other medically important Candida species and organisms in other kingdoms. The alignment was generated by using the UniProt alignment function (www.uniprot.org). The amino acid numbering is based on the C. albicans sequence. The conserved amino acids are highlighted in blue. The amino acid substitutions in red type are those observed in this study. The substitutions in black type have been noted in the literature (13). The following GenBank accession numbers were used: C. albicans, P1613; Candida tropicalis, P14263; S. cerevisiae, P1614; Candida glabrata, P50859; C. krusei, Q02315; human (Homo sapiens), Q16850; Mycobacterium tuberculosis, P0A512; Triticum aestivum, P93596. a.a., amino acid.