Table 1.
Gene Ontology analysis of differentially methylated genes in fetal versus adult livers
| A. Top 10 biological processes associated with hypomethylated genes in adult livers | |||
|---|---|---|---|
| Term Name | P-value | Fold enrich. 1 | Obs. regions 2 |
| Steroid metabolic process | 2.77E-52 | 2.03 | 558 |
| Regulation of lipid metabolic process | 4.42E-51 | 2.06 | 528 |
| Regulation of generation of precursor metabolites and energy | 5.62E-48 | 3.24 | 216 |
| Regulation of glycolysis | 1.15E-44 | 5.21 | 116 |
| Sterol metabolic process | 4.28E-44 | 2.56 | 288 |
| Positive regulation of lipid metabolic process | 3.52E-43 | 2.48 | 300 |
| Regulation of cellular carbohydrate catabolic process | 3.26E-42 | 4.22 | 136 |
| Regulation of lipid transport | 3.88E-42 | 3.54 | 168 |
| Cholesterol metabolic process | 3.71E-40 | 2.51 | 271 |
| Regulation of cellular ketone metabolic process | 4.25E-39 | 2.11 | 381 |
| B. Top 10 biological processes associated with hypomethylated genes in fetal livers | |||
| Term Name | P-value | Fold enrich. 1 | Obs. regions 2 |
| Insulin receptor signalling pathway | 1.74E-130 | 77.00 | 88 |
| Positive regulation of glycogen (starch) synthase activity | 1.69E-105 | 37.19 | 90 |
| Anterior/posterior pattern specification | 1.27E-96 | 2.26 | 813 |
| Regulation of gene expression by genetic imprinting | 2.36E-92 | 10.52 | 143 |
| Regulation of glycogen (starch) synthase activity | 3.97E-81 | 19.01 | 91 |
| Genetic imprinting | 3.54E-69 | 6.66 | 147 |
| Response to estrogen stimulus | 4.52E-69 | 2.14 | 657 |
| Positive regulation of insulin receptor signalling pathway | 9.60E-68 | 11.64 | 98 |
| Positive regulation of cell cycle | 2.83E-61 | 2.51 | 421 |
| Luteinizing hormone secretion | 4.18E-61 | 11.24 | 90 |
1Fold enrichment - fold enrichment of number of genomic regions in the test set with the annotation.
2Observed region hits - actual number of genomic regions in the test set with the annotation.