Table 9.
Mean per cent changes in clinical laboratory parameters from baseline to week 52
| Parameter | PBO | CANA 100 mg | CANA 300 mg |
|---|---|---|---|
| ALT, n | 88 | 107 | 108 |
| Mean baseline (U/l) | 28.6 | 29.4 | 29.7 |
| Mean (SD) per cent change | 6.6 ± 48.2 | –3.8 ± 31.5 | –9.7 ± 33.2 |
| BUN, n | 89 | 108 | 109 |
| Mean baseline (mmol/l) | 5.6 | 5.5 | 5.6 |
| Mean (SD) per cent change | 5.5 ± 24.5 | 14.5 ± 29.0 | 17.5 ± 29.3 |
| Chloride | 89 | 108 | 109 |
| Mean baseline (mmol/l) | 101.6 | 101.4 | 101.5 |
| Mean (SD) per cent change | 0.1 ± 2.9 | 0.6 ± 2.6 | 0.6 ± 2.3 |
| Creatinine | 89 | 108 | 109 |
| Mean baseline (μmol/l) | 72.9 | 70.3 | 71.3 |
| Mean (SD) per cent change | 2.8 ± 12.2 | 2.5 ± 11.8 | 7.7 ± 20.5 |
| eGFR, n | 89 | 108 | 109 |
| Mean baseline (ml/min/1.73 m2) | 87.4 | 91.0 | 91.9 |
| Mean (SD) per cent change | –1.9 ± 12.9 | –1.6 ± 13.7 | –5.8 ± 14.5 |
| Magnesium, n | 89 | 108 | 109 |
| Mean baseline (mmol/l) | 0.8 | 0.8 | 0.8 |
| Mean (SD) per cent change | –1.1 ± 7.8 | 7.1 ± 10.3 | 9.7 ± 9.5 |
| Phosphate, n | 89 | 108 | 109 |
| Mean baseline (mmol/l) | 1.2 | 1.2 | 1.2 |
| Mean (SD) per cent change | 4.6 ± 15.0 | 2.2 ± 14.6 | 4.2 ± 14.5 |
| Potassium, n | 89 | 108 | 109 |
| Mean baseline (mmol/l) | 4.4 | 4.4 | 4.4 |
| Mean (SD) per cent change | 1.7 ± 9.9 | 1.3 ± 10.0 | 0.6 ± 8.7 |
| Sodium, n | 89 | 108 | 109 |
| Mean baseline (mmol/l) | 139.4 | 139.6 | 139.5 |
| Mean (SD) per cent change | 0.7 ± 2.4 | 0.7 ± 1.9 | 0.5 ± 1.8 |
| Urate, n | 89 | 108 | 109 |
| Mean baseline (μmol/l) | 332.9 | 322.3 | 340.1 |
| Mean (SD) per cent change | 0.7 ± 20.2 | –8.8 ± 20.4 | –9.4 ± 17.5 |
| Haemoglobin, n | 86 | 105 | 107 |
| Mean baseline (g/l) | 142.4 | 140.1 | 141.4 |
| Mean (SD) per cent change | –1.6 ± 6.0 | 4.2 ± 5.7 | 4.4 ± 5.8 |
PBO, placebo; CANA, canagliflozin; ALT, alanine aminotransferase; SD, standard deviation; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate.