Table A4.
HRs for Death by Diabetes Status Stratified by Covariates Among Patients With Pancreatic Cancer From NHS and HPFS
| Covariate | No. of Patients | Diabetes Status at Diagnosis* |
P (interaction)† | ||||
|---|---|---|---|---|---|---|---|
| No Diabetes | Short Term (≤ 4 years) |
Long Term (> 4 years) |
|||||
| HR | HR | 95% CI | HR | 95% CI | |||
| Sex | .80 | ||||||
| Female (NHS) | 635 | 1.0 | 0.97 | 0.68 to 1.39 | 1.43 | 1.12 to 1.82 | |
| Male (HPFS) | 371 | 1.0 | 1.19 | 0.69 to 2.07 | 1.35 | 0.99 to 1.85 | |
| Smoking status | .66 | ||||||
| Never | 402 | 1.0 | 1.12 | 0.70 to 1.78 | 1.56 | 1.14 to 2.14 | |
| Ever | 584 | 1.0 | 0.94 | 0.63 to 1.39 | 1.32 | 1.04 to 1.68 | |
| BMI, kg/m2 | .98 | ||||||
| < 25 | 419 | 1.0 | 0.97 | 0.60 to 1.57 | 1.51 | 1.04 to 2.20 | |
| ≥ 25 | 492 | 1.0 | 1.16 | 0.78 to 1.74 | 1.39 | 1.09 to 1.77 | |
| Cancer stage | .54 | ||||||
| Localized | 149 | 1.0 | 1.43 | 0.64 to 3.18 | 1.18 | 0.65 to 2.12 | |
| Locally advanced | 116 | 1.0 | 1.28 | 0.57 to 2.84 | 1.19 | 0.58 to 2.42 | |
| Metastatic | 480 | 1.0 | 1.15 | 0.74 to 1.80 | 1.45 | 1.11 to 1.88 | |
Abbreviations: BMI, body-mass index; HPFS, Health Professionals Follow-Up Study; HR, hazard ratio; NHS, Nurses' Health Study.
*
Adjusted for age at diagnosis (continuous), sex (male or female), race/ethnicity (white, black, other, or unknown), smoking status (never, past, current, or missing), year of diagnosis (continuous), and stage at diagnosis (localized, locally advanced, metastatic, or unknown), excluding stratification covariate.
†
P interaction for long-term diabetics compared with nondiabetics.