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Nucleotide binding affinities and intrinsic GTP hydrolysis rates of relevant NRAS isoforms.
| RAS Mutant |
GDP Off | GDP off + 1:2 SOScat | GMPPNP Off | GMPPNP Off + 1:2 SOScat | Intrinsic Hydrolysis |
|---|---|---|---|---|---|
| Rate (s−1 × 10−4) | Rate (s−1 × 10−4) | Rate (s−1 × 10−4) | Rate (s−1 × 10−4) | Rate (s−1 × 10−4) | |
| NRASWT | 1.5 ± 0.2 | 8.0 ± 0.7 | 1.7 ± 0.4 | 9.8 ± 0.9 | 4.6 ± 0.4 |
| NRASG12D | 1.3 ± 0.3 | 3.3 ± 0.4 | 1.6 ± 0.5 | 3.9 ± 0.6 | 2.3 ± 0.5 |
| NRASQ61R | 1.1 ± 0.2 | 1.3 ± 0.3 | 0.4 ± 0.2 | 0.5 ± 0.2 | 0.002 ± 0.03 |
