Table 4. Top Significant GO Terms Identified by PSEA-Quant As Enriched for Upregulated Proteins with Low Coefficient of Variation in Human vs Mouse in the Human, Mouse, and Rat (HMR) Frontal Cortex TMT protein quantification dataset (q-value < 0.02)a.
| GO term | p-value | q-value | number of proteins with GO term in HMR data set |
|---|---|---|---|
| mitochondrial respiratory chain complex I | <10–5 | 0.01 | 38 |
| NADH dehydrogenase (quinone) activity | <10–5 | 0.01 | 30 |
| blood coagulation | <10–5 | 0.01 | 90 |
| protein folding | <10–5 | 0.01 | 88 |
| hydrogen ion transmembrane transporter activity | <10–5 | 0.01 | 48 |
| mitochondrial electron transport, NADH to ubiquinone | <10–5 | 0.01 | 28 |
| single-organism metabolic process | <10–5 | 0.01 | 1014 |
| respiratory electron transport chain | <10–5 | 0.01 | 65 |
| cofactor binding | <10–5 | 0.01 | 138 |
| cytoplasmic membrane-bounded vesicle lumen | <10–5 | 0.01 | 25 |
| catabolic process | <10–5 | 0.01 | 640 |
| oxidoreductase activity, acting on NAD(P)H | <10–5 | 0.01 | 56 |
| antioxidant activity | <10–5 | 0.01 | 33 |
| mitochondrial membrane part | <10–5 | 0.01 | 105 |
| extracellular matrix | <10–5 | 0.01 | 69 |
| mitochondrion | <10–5 | 0.01 | 672 |
| response to oxidative stress | <10–5 | 0.01 | 95 |
| hemostasis | <10–5 | 0.01 | 92 |
| cytosol | <10–5 | 0.01 | 765 |
| monocarboxylic acid metabolic process | <10–5 | 0.01 | 147 |
| organelle membrane | <10–5 | 0.01 | 738 |
| intracellular organelle lumen | <10–5 | 0.01 | 178 |
| platelet activation | <10–5 | 0.01 | 48 |
| cell activation | <10–5 | 0.01 | 104 |
| regulation of body fluid levels | <10–5 | 0.01 | 113 |
| protease binding | <10–5 | 0.01 | 19 |
| platelet degranulation | <10–5 | 0.01 | 28 |
| mitochondrial part | <10–5 | 0.01 | 402 |
| generation of precursor metabolites and energy | <10–5 | 0.01 | 151 |
| carboxylic acid metabolic process | <10–5 | 0.01 | 336 |
| oxoacid metabolic process | <10–5 | 0.01 | 351 |
| melanosome | 1.0 × 10–5 | 0.01 | 52 |
| organic acid catabolic process | 1.0 × 10–5 | 0.01 | 91 |
| sulfur compound metabolic process | 1.0 × 10–5 | 0.01 | 78 |
| cellular amino acid metabolic process | 1.0 × 10–5 | 0.01 | 186 |
| lipid metabolic process | 1.0 × 10–5 | 0.01 | 303 |
| xenobiotic metabolic process | 2.0 × 10–5 | 0.01 | 30 |
| small molecule catabolic process | 2.0 × 10–5 | 0.01 | 113 |
| GTPase activity | 2.0 × 10–5 | 0.01 | 113 |
| organonitrogen compound metabolic process | 2.0 × 10–5 | 0.01 | 558 |
| cellular modified amino acid metabolic process | 3.0 × 10–5 | 0.01 | 82 |
| cell junction assembly | 3.0 × 10–5 | 0.01 | 54 |
a
Redundant GO terms were removed and p-values and q-values were rounded.