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. Author manuscript; available in PMC: 2015 Nov 4.
Published in final edited form as: Cell Metab. 2014 Oct 9;20(5):898–909. doi: 10.1016/j.cmet.2014.09.003

Fig. 3. Lack of CNS insulin signaling leads to impaired regulation of BCAA metabolism.

Fig. 3

A) Schematic representation of fasting and refeeding protocol in NIRKO mice. B) Plasma BCAA levels at fasting and refed state in NIRKO mice (n ≥ 5 per group). C) Plasma BCAA levels in IRΔWB mice after overnight fasting (n = 8 per group). D) Plasma BCAA levels in IRΔPER mice after overnight fasting (n ≥ 7 per group). E) Hepatic protein expressions of BCKDH and phosphorylated, inactive form of BCKDH by Western blot in IRΔWB mice after overnight fasting (n ≥ 4 per group). F) Hepatic protein expressions of BCKDH and phosphorylated, inactive form of BCKDH by western blot in IRΔPER mice after overnight fasting (n ≥ 4 per group). * p<0.05 compared to control group. Values are mean±SEM.