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. 2014 Nov;58(11):6790–6806. doi: 10.1128/AAC.03746-14

TABLE 1.

Plasma SAHA levels in cART-suppressed macaques

Animal SAHA course no. Dosage (mg/kg) Sampling day during 21-day SAHA treatment Timing of sampling post-SAHA dose (h) Plasma [SAHA] (μM)
DC1G 1 Predose BLQa
45 7 2 0.231
45 14 2 0.484
45 21 2 0.644
2 45 7 2 0.183
45 21 2 0.039
3 Predose BLQ
57 1 4 0.040
57 14 4 0.231
57 21 4 0.012
4 57 8 4 0.032
57 14 4 0.044
57 21 4 0.201
DCEA 1 Predose BLQ
45 7 2 0.137
45 14 2 0.021
45 21 2 0.137
2 45 7 2 BLQ
45 14 2 BLQ
45 21 2 0.018
3 Predose BLQ
57 1 4 BLQ
57 7 4 BLQ
57 14 4 BLQ
57 21 4 0.012
4 57 7 4 0.002
57 14 4 BLQ
57 21 4 0.013
DCEW 1 Predose BLQ
45 7 2 0.651
45 14 2 0.451
45 21 2 0.344
2 45 7 2 0.081
45 14 2 0.167
45 21 2 0.027
3 Predose BLQ
57 1 4 0.012
57 14 4 0.003
57 21 4 0.037
4 57 7 4 0.011
57 14 4 0.036
57 21 4 0.044
DCCP 1 Predose BLQ
45 7 2 0.087
45 14 2 0.028
45 21 2 0.087
2 45 7 2 0.007
45 21 2 0.056
3 Predose BLQ
57 1 4 0.012
57 7 4 0.011
57 21 4 0.005
4 57 1 4 0.007
57 8 4 0.009
57 21 4 0.396
DCLJ 1 Predose BLQ
45 7 2 0.025
45 14 2 0.025
45 21 2 0.248
2 45 1 2 0.032
45 7 2 0.185
45 21 2 0.069
3 Predose BLQ
57 1 4 0.017
57 14 4 0.060
4 57 1 4 0.426
57 7 4 0.026
57 21 4 0.027
DCT2 1 Predose BLQ
45 7 2 0.080
45 14 2 0.043
45 21 2 0.080
2 45 7 2 0.003
45 21 2 BLQ
3 Predose BLQ
57 1 4 BLQ
57 14 4 BLQ
4 57 1 4 BLQ
57 7 4 0.005
57 21 4 BLQ
a

BLQ, below the level of quantification (<0.002 μM).