. Author manuscript; available in PMC: 2014 Dec 27.

Published in final edited form as: Nature. 2014 Sep 21;515(7528):554–557. doi: 10.1038/nature13761

Extended Data Table 2.

Lists of scFvs and human proteins used in the binding profiling

ScFv #	Original mAb	Construction method	Binding target
1-20	Anrukinzumab	V_H-linker-V_L	IL13
21-40	Ustekinumab	V_H-linker-V_L	IL12B
41-60	Canakinumab	V_H-linker-V_L	IL1B
61-80	Conatumumab	V_H-linker-V_L	TNFRSF10B
81-100	Ibalizumab	VH-linker-VL	CD4
101-120	Oportuzumab	V_H-linker-V_L	CD326
121-140	Otelixizumab	V_H-linker-V_L	CD3E
141-160	Ranibizumab	V_H-linker-V_L	VEGFA
161-180	Siltuximab	V_H-linker-V_L	IL6
181-200	Tanezumab	V_H-linker-V_L	NGF

Human protein #	Entrez Gene symbol	Entrez Gene ID	Protein length (a.a.)
1	IL1B	3553	270
2	IL2	3558	154
3	IL3	3562	153
4	IL4	3565	154
5	IL6	3569	212
6	IL7	3574	178
7	IL8	3576	100
8	IL9	3578	145
9	IL10	3586	179
10	IL12B	3593	328
11	IL13	3596	147
12	IL15	3600	163
13	IL17A	3605	156
14	IL17B	27190	181
15	IL17F	112744	164
16	IL18	3606	194
17	IL20	50604	177
18	IL25	64806	178
19	IL26	55801	172
20	IL28A	282616	201
21	IL29	282618	201
22	IL31	386653	165
23	CD1A	909	312
24	CD1E	913	334
25	CD3E	916	208
26	CD4	920	459
27	CD7	924	241
28	CD27	939	261
29	CD38	952	301
30	CD40	958	278
31	CD52	1043	62
32	CD58	965	241
33	CD59	966	129
34	CD79B	974	230
35	CD74	972	233
36	CD80	941	289
37	CD207	50489	329
38	CD247	919	165
39	CD274	29126	291
40	CD302	9936	171
41	CD320	51293	283
42	CD326	4072	314
43	CNTF	1270	201
44	CSF2	1437	145
45	CSF3	1440	201
46	NGF	4803	241
47	NODAL	4838	348
48	OSM	5008	253
49	THPO	7066	350
50	VEGFA	7422	237
51	FASLG	356	282
52	LTA	4049	206
53	TNF	7124	234
54	TNFRSF10B	8795	440
55	TNFRSF13B	23495	248