Table 1.
Baseline characteristics of subjects†.
| All subjects | Subjects requiring extra carbohydrates‡ | Subjects not requiring extra carbohydrates‡ | |
|---|---|---|---|
| Number | 11 | 5 | 6 |
| Sex | 7M / 4F | 5M | 2M / 4F |
| Age (years) | 40 ± 16 (19–71) | 47 ± 19 (19–71) | 34 ± 13 (20–50) |
| BM (kg) | 83 ± 13 (66–110) | 90 ± 12 (79–110) | 78 ± 11 (66–95) |
| BMI (kg/m2) | 28 ± 3 (22–31) | 27 ± 4 (22–31) | 28 ± 3 (22–31) |
| Diabetes Duration (years) | 23 ± 13 (6–46) | 30 ± 17 (6–46) | 17 ± 4 (9–21) |
| HbA1c (%) | 7.3 ± 0.8 (6.2–8.5) | 7.4 ± 1.0 (6.4–8.5) | 7.3 ± 0.7 (6.2–8.1) |
| Daily insulin dose (U/kg) | 0.6 ± 0.2 (0.3–1.0) | 0.5 ± 0.2 (0.3–0.8) | 0.7 ± 0.2 (0.5–1.0) |
| Stimulated c-peptide* (nmol/L) | < 0.03 | < 0.03 | < 0.03 |
†
Results are expressed as mean ± SD (range), unless otherwise stated.
‡
Hypoglycemia was treated with extra carbohydrates (15 g) if BG remained below 60 mg/dL for a 20-minute period, below 50 mg/dL for a 10-minute period, or if subjects were symptomatic (see Supplementary Appendix).
*
All subjects had undetectable fasting and stimulated c-peptide, reported as less than the assay limit.